Gris oscuro (#496682)

Psychosis

Nuestro grupo de investigación es probablemente el de más larga trayectoria sobre Psicosis en nuestro país ya que comenzó su andadura en 1988, dando sus primeras producciones científicas en 1991. Desde entonces y hasta la fecha actual se han realizado publicaciones científicas cada año con un total de más de 190 publicaciones indexadas en las revistas científicas de mayor impacto de la especialidad.

Actualmente se colabora activamente con el Departamento de Biología Animal de la Universidad de Barcelona, con el Departamento de Matemáticas e Ingeniería de la Universidad Pública de Navarra, así como con 20 centros hospitalarios psiquiátricos nacionales de prestigio contrastado en tres proyectos financiados por el Instituto de Salud Carlos III.

Investigador principal
Área de investigación
Mental health
Trayectoria del grupo de investigación en Psicosis
Unidad de investigación / Grupo Vinculado
Contacto
Psychosis

Navarrabiomed - Centro de investigación biomédica
Complejo Hospitalario de Navarra, edificio de investigación.
Calle Irunlarrea, 3. 31008 Pamplona, Navarra, España.

Geriatrics and Active Ageing (INGEA)

Geriatrics

This team carry out research on different aspects of ageing, particularly, the complexity of multiple pathologies and polypharmacy situations.

Lines of research:

  • Multimorbidity and polypharmacy.
  • Frailty, sarcopenia and disability.
  • The elderly in nursing homes and the community.
     
Investigador principal
Área de investigación
Active and healthy life
Lines of research into ageing
Actualidad

APTITUDE and OPTIMAGE: cross-border research to improve the quality of life of the elderly

Author
Navarrabiomed

The results of these projects, fronted in the Foral Community by Navarrabiomed in collaboration with the HUN, have been presented during the Scientific Conference “New horizons in aging and health”.

The teams of the Cross-border APTITUDE and OPTIMAGE projects have disclosed the results during the scientific conference “New horizons in aging and health”, held this morning in Pamplona. Both projects, 65% co-financed by the European Regional Development Fund (ERDF) through the Interreg V-A Spain-France-Andorra Program (POCTEFA 2014-2020), have made it possible to deploy, in the cross-border area of the Pyrenees, dependence prevention actions for the elderly, through the creation of a network of experts that promote care, training, research and innovation in gerontology. 


Identifying fragility

The APTITUDE project is an initiative aimed at the creation of a cross-border structuring framework for cooperation in the care of the elderly.  Dr. Nicolás Martinez Velilla, head of the Geriatrics Research Unit of Navarrabiomed and Head of the Geriatrics Service of the University Hospital of Navarra, leads these initiatives the challenge being “not to live longer but to live better by preventing dependence and improving the quality of life of our elders.” Martinez has stressed the importance of putting the focus on the elderly: "aging is an outdated concept that encompasses very heterogeneous and complex realities. Depending on the degree of dependence, there are several concepts of frailty that we have to address globally thinking about the affected person, not the disease.” 

For this purpose, a network of experts that promotes gerontological care, training, research and innovation has been created. “It is essential to identify the fragile person so that, among all the different health professionals, we focus on them.” In this regard, with the aim of more accurately diagnosing the status of this sector of the population in our region and improving multidisciplinary cooperation between geriatricians and other health professionals, a screening of frailty exists in which 105 Navarreses with an average age of 78 years have participated. 

As he explained by Fabricio Zambon Ferraresi, researcher of Navarrabiomed, “the actions undertaken within the framework of the projects have been developed in the midst of the COVID health crisis, a particularly difficult situation for the elderly, who needed us more than ever.” Proof of this are the online training sessions of the Vivifrail Promotion of Physical Exercise or videos with practical tips to face the negative effects derived from confinement, aimed at older people during the months of lockdown.  
In addition, at the University Hospital of Navarra itself, an image tour of Navarra has been created to promote the physical and cognitive activity of hospitalized elderly people and work has also been done on the prevention of disability in rural areas.

Preventing pharmacological iatrogenesis

The objective of OPTIMAGE, which emerged as a result of APTITUDE, focuses on the optimization of pharmacotherapy in the elderly - stage in which some people are polymedicated taking up to 10 or 12 different drugs simultaneously - to avoid unintentional harm to the patient that leads to more hospital admissions and a poorer quality of life. These risks are technically called “pharmacological iatrogenesis". 

Victoria Roncal, regional coordinator of the OPTIMAGE project in Navarrabiomed, reveals that the project has allowed a more intense collaboration between the Geriatrics and Pharmacy services of the University Hospital of Navarra, within a specific consultation formed by a multidisciplinary team that addresses the challenges of polypharmacy. The specific incorporation of a specialist pharmacist to the Geriatrics team has meant a greater monitoring of the patient's pharmacotherapy, in the context of comprehensive geriatric assessment in all its facets: clinical, cognitive, social and functional, with the aim of achieving pharmacological optimization of both outpatient and inpatient geriatric patients. Specifically, between December 2020 and April 2022, the treatment of 1,025 hospitalized patients has been evaluated and, between May 2021 and April 2022, the pharmacotherapy of 317 people who have made a first visit to this specific service has been reviewed. 

Also within the framework of OPTIMAGE, good practices have been exchanged between health professionals from the different territories and a training cycle has been organized for community pharmacy professionals to transmit practical knowledge on the review of treatments in elderly people. 
On the other hand, Optipharm has been developed, a “game” in which a clinical case on pharmacological optimization in elderly people is recreated virtually. This application offers a safe simulation environment to make decisions and put into practice help tools for the optimization of pharmacotherapy in elderly people. 
Pharmacological iatrogenesis has been the focus of debate in a round table with the participation of María Javier Ramírez, Dean of the Faculty of Pharmacy and Nutrition - University of Navarra, Maite Sarobe, Head of the Pharmacy Service of the HUN- SNS-O and Javier Garjón, Head of the Drug Advisory and Information Service- SNS-O. All three have emphasized the safety of medicines and the tools or methodologies especially focused on the safety and prevention of this problem. 

Globalization of public health research

Both cooperation projects are clear examples of Navarrabiomed - Miguel Servet Foundation's commitment to globalize research in the public health system. Coinciding with the program of events organized and coordinated by the General Directorate of External Action of the Government of Navarra on the occasion of the European Week in Navarra, Marisol Fragoso, management director of Navarrabiomed, has stressed the importance of participating in European projects for the internationalization of research in the public health system of Navarra: "In addition, being an important source of funding, it further qualifies our researchers by increasing their competitiveness and allows access to other agents of the research system such as companies and universities, developing collaborations that consolidate and remain over time”. 
International meeting and workshops for the elderly.

During the conference, aging was also addressed by leading experts from the United Kingdom, Ireland and Chile.  Felipe Prosper, specialist in Haematology and Cell Therapy of the Navarra University Clinic and deputy director of IdiSNA has concluded this first block entitled "From molecules to patients". The scientific conference was closed by María Pilar Gayoso, deputy director general of Research in Cell Therapy and Regenerative Medicine of the Carlos III Health Institute.
In parallel, in Rincón de la Aduana, workshops have been organized that encouraged citizens to "take care of themselves and be a healthy senior”. Those interested have participated in seven activities: dance with Lorea Esparza, olfactory stimulation techniques within the framework of the Innolfact project, the Vivifrail physical exercise program promoted by Navarrabiomed and the University Hospital of Navarra, healthy habits and nutrition, new technologies and cognitive stimulation managed by the Red Cross. In addition, the Official Association of Pharmacists of Navarra, COFNA, has made available an information point on therapeutic adherence. 

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CHN and Navarrabiomed present, in Navarre, the European OPTIMAGE network to optimize drug therapy in the elderly

Author
Navarrabiomed
  • The online event was held yesterday with the participation of more than 150 professionals from hospital, community, social health and research settings

The Navarrabiomed Biomedical Research Center, together with the Hospital Complex of Navarre (CHN), organized an online presentation yesterday to introduce the European OPTIMAGE network in Navarre. OPTIMAGE is being developed within the framework of the Interreg Program V-A Spain-France-Andorra (POCTEFA 2014-2020) under the leadership of the University Hospital Center of Toulouse. More than 150 people from hospital, community and social health settings participated in the event, as well as research and business professionals, not to mention representatives from patients’ associations and members of the public.
 
The goal of OPTIMAGE is to optimize drug therapy in the elderly (an age bracket in which polypharmacy can be common, with some patients taking 10 or 12 different drugs) to avoid adverse effects that can lead to extended hospital stays and worsening of the patient’s prognosis. This situation is technically known as drug iatrogenesis. The project’s aim is to prevent this phenomenon through better cooperation among healthcare professionals on using drugs appropriately. Pharmacists are therefore key members of the multidisciplinary team, which also includes healthcare professionals working to prevent drug iatrogenesis.

Leading the initiative is Nicolás Martínez Velilla, Head of the Navarrabiomed Geriatrics Research Unit and also Head of the CHN Geriatrics Service, who highlighted the network’s multicenter structure. “With OPTIMAGE, we want to join the forces of all agents at the Navarre Health Service by implementing pharmacological optimization, providing instruction, encouraging professionals to take part in internships in different regions in the Pyrenees, and sharing and standardizing protocols and good practices,” Martínez said.
 
Besides Nicolás Martínez, the following people spoke at the presentation: Marisol Fragoso Roanes, Managing Director of Navarrabiomed, Alfredo Martínez Larrea, Managing Director of the CHN, Antonio López Andrés, Assistant Director of Pharmacy and Care at the Navarre Health Service (SNS-O), and Maite Sarobe Carricas, Head of the CHN Pharmacy Service. They all showed their support for this network project, which calls for close management and coordination between the services and units involved.

Maite Sarobe said that OPTIMAGE would considerably improve patient care. She went on to say, “This project gives us the chance to improve care by means of specific polypharmacy screening at the Geriatrics Service, where the goal is to optimize therapeutics among the elderly.” She also stressed the importance of monitoring and supervising drug therapy in the elderly, detecting any interactions, confirming the suitability of the drug and its optimal dose in each case, and understanding that the patient’s suffering may be due to the drug prescribed, as well as the suitability of the drug to the patient’s lifestyle, caregivers and setting.

Other participants at the presentation were Daniel Villanueva Canabal and Victoria Roncal Belzunce, Navarrabiomed project manager and project coordinator, respectively; Ramón San Miguel Elcano, specialist in hospital pharmacy at the CHN; Javier Garjón Parra, Head of the Drug Advisory and Information Service at the SNS-O; and Cecilia Calvo Pita and Goizane Ros Bernaola, specialists in hospital pharmacy at the SNS-O.

Strategic axes

The OPTIMAGE network was created as part of the APTITUDE network for the prevention of dependence in the elderly. OPTIMAGE aims to bolster and complement APTITUDE by including community and hospital pharmacists. Consortium members besides Navarrabiomed include the University Hospital Center of Toulouse (project leader), the Health and Aging Foundation of the Universitat Autònoma de Barcelona and the Andorran Health Service.
The project will operate for 29 months along three main axes: the creation of a network against drug iatrogenesis made up of professionals, patients and family members; the training of different social groups; and the implementation of actions for the elderly to improve drug management, and helping develop the European gerontology excellence center begun by APTITUDE.

Cooperation between professionals is a key means of preventing drug iatrogenesis. The exchange of knowledge across the Pyrenees will therefore help provide a clearer view of the strengths and weaknesses of each territory in the areas of the optimization of drug therapy in geriatrics, the prevention of drug iatrogenesis, therapeutic education, teaching and innovation.

The project is co-funded (65%) by the European Regional Development Fund (ERDF) through the Interreg Program V-A Spain-France-Andorra (POCTEFA 2014-2020). The goal of the POCTEFA program is to strengthen the economic and social integration of the Spain-France-Andorra cross-border area. Its help is focused on developing cross-border economic, social and environmental projects through joint strategies in favor of sustainable regional development.
 

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Left to right: Nicolás Martínez, Alfredo Martínez, Marisol Fragoso, Antonio López, Maite Sarobe, Daniel Villanueva and Victoria Roncal.
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OPTIMAGE event.
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Evento de lanzamiento del proyecto europeo OPTIMAGE en Navarra
Nicolás
Martínez Velilla
Investigador principal

Professional scientific seminar and open workshops on active ageing, organised by European network APTITUDE

Author
Navarrabiomed

The European network APTITUDE - Acting for Trans-Pyrenees Prevention of Dependency in Seniors – is gathering in Pamplona on Wednesday, 3 July for a scientific seminar that is expected to draw more than 200 experts in active ageing and frailty. The seminar will take place at the Tres Reyes Hotel in Pamplona, starting at 8.15am. In addition, there will be side workshops organised with the Navarra Red Cross for the general public, at Rincón de la Aduana and Paseo del Doctor Arazuri, starting at 10am.

These events were introduced this morning at the biomedical research centre Navarrabiomed, the network’s leading institution in Navarra, along with the Public University of Navarre (UPNA), the Navarra Hospital Complex (CHN) and the Navarra Red Cross. At the press conference were Nicolás Martínez Velilla, APTITUDE Coordinator in Navarra and Head of the Geriatrics Unit at CHN, Juan José San Martín Baquedano, Coordinator of the Navarra Red Cross, and Jorge Marín Vidondo, Project Manager at Navarrabiomed.

Martínez Velilla said the seminar would be the third APTITUDE meeting – and the first to take place in Pamplona. It will gather primary health care professionals and representatives of hospitals and research centres, universities, nursing homes and businesses from Occitanie in France, Catalonia and Navarra in Spain, and Andorra.
At the seminar, experts will discuss the concept of intrinsic capacity in older individuals – that is, the set of physical and mental skills an individual can apply at any given moment, plus the functional capacity, which is the way in which an individual relates to and interacts with the environment – proposed by the World Health Organisation (WHO). Also, they will talk about the multi-component training offered by the project, targeted at health and social care practitioners working with frail seniors, so that they can prescribe the adequate physical activity routines, make cognitive stimulation interventions, give healthy diet guidelines, make psycho-social interventions, etc.

Keynote speakers include Norman Lazarus and Stephen Harridge, from King’s College London, who have broad experience in physical activity, anti-ageing and muscle deterioration in geriatric care and other sectors, like aerospace, where they have worked with NASA.

Open workshops

On Wednesday, between 10am and 2pm, there will be open workshops at Rincón de la Aduana and Paseo del Doctor Arazuri, Pamplona. Under the title ‘Active, healthy seniors/Tailerrak: Adineko aktibo eta osasuntsuak’, they are targeted at people over 65, but they can also be of interest to caretakers, relatives or volunteers. The workshops are free and no prior registration is required.

In addition, there will be APTITUDE-Red Cross Tents, hosting functional assessment, cognitive stimulation and adapted leisure activities for the elderly, giving information about support devices and healthy habits, and giving out supplementary material with workout routines.

Ageing and functional decline

According to INE data from 2018, the population of Navarra amounts to 647,219 people, 19.5 per cent are 65 or above. The region has one of the longest life expectancies in Europe: 86.6 years for women and 81 years for men. However, the quality of life varies: whereas women tend to live longer lives, they become more dependent than men after 65.

According to the World Health Organisation, the main causes of mild or severe disability in old age are sensory impairment, back or neck pain, chronic obstructive pulmonary disease (COPD), depression, falls, diabetes mellitus, dementia and osteoarthritis. Moreover, more than 50 per cent of the elderly suffer from a combination of illnesses and take three to five medicines together.

Initiatives like APTITUDE advocate a change of paradigm in elderly care. Caretakers should face the challenge of setting illness aside to focus on functional capacity and its maintenance or improvement. APTITUDE promotes healthy habits, physical activity and cross-generational, adapted leisure both in urban centres and rural environments, in an effort to combat loneliness, depopulation in rural areas and the stereotypes associated with ageing.

About APTITUDE

APTITUDE was established in 2018 as a three-year network to foster cross-border cooperation in four regions (Occitanie, Catalonia, Navarra and Andorra) by building its own local networks with a total budget of 2 million Euro.
The APTITUDE project, which includes the APTITUDE network in Navarra, gets 65 per cent of its funds from the European Regional Development Fund (ERDF), through the Interreg V-A Spain-France-Andorra (POCTEFA) cooperation programme, aimed at the development of cross-border economic, social and environmental action by means of joint strategies to promote sustainable territorial development.

APTITUDE partners:

Gérontopôle - Centre Hospitalier Universitaire (CHU) de Toulouse
Fundació Salut i Envelliment - Universitat Autònoma de Barcelona (UAB)
Servei Andorrà d’Atenció Sanitària
Complejo Hospitalario de Navarra (CHN) - Navarrabiomed

More information: www.aptitude-net.com

 

Photo: From left to right: Jorge Marín (Navarrabiomed), Nicolás Martínez (CHN-Navarrabiomed) and Juan José San Martín (Navarra Red Cross).

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Jorge Marín, Nicolás Martínez and Juanjo San Martín.
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CHN, UPNA and Navarrabiomed participate in the creation of European network for preventing old-age dependency and promoting active ageing

Author
Navarrabiomed

Professionals at the Navarra Hospital Complex (CHN) from the Public University of Navarra (UPNA) and Navarrabiomed are participating in the establishment of a European network for preventing old-age dependency and promoting active ageing. Hospitals and research centres from France, Spain (Navarra and Catalonia) and Andorra are part of this project, named APTITUDE (Acting for Trans-Pyrenees Prevention of Dependency in Seniors). As announced today, the network in Navarra is being coordinated by Navarrabiomed-Miguel Servet Foundation.

The three-year cross-border project will develop local networks in France, Navarra, Catalonia and Andorra. The project has been assigned a 2-million-Euro budget, with 1 million going to Spain (and 400,000 to Navarra). 65 per cent of the funds are being contributed by the European Regional Development Fund (ERDF) through the Interreg V-A Spain programme.

Through training programmes, awareness-raising activities and scientific evidence, the project is aimed at improving the quality of life of elderly people, encouraging the adoption of healthy habits and reducing the loss of functional autonomy, as explained by Antonio Merino Díaz de Cerio, CHN Managing Director, and Nicolás Martínez Velilla, Head of the Geriatrics Department, researcher at the Geriatrics Unit in Navarrabiomed and leader of APTITUDE in Navarra. In the words of Martínez Velilla, ‘the primary goal of the network is to prevent old-age dependency by trying to mitigate frailty in the elderly population.’

Antonio Merino stressed the importance of this type of European projects where protocols, good practices and procedures are shared for the benefit of all the participating institutions and society at large.

Specific actions by APTITUDE Navarra

Álvaro Casas Herrero, geriatrician at CHN and President of the Spanish Geriatrics Society, and Maite Soria Sarnago, Nursing Director at CHN, announced the actions to be undertaken in our community in the forthcoming months.

On Tuesday, 20 November, the project will be presented at a talk in the function room of the School of Medical Sciences, titled ‘Active and healthy seniors: Keys for adopting healthy habits’. The talk will start at 4pm and finish at 6.30pm. Admission is free, but there will be a limited number of seats available. It will also be streamed on the Navarrabiomed YouTube channel.

At the event, the leaders of the project will talk about healthy habits and good practices for improving the quality of life of old people. The President of Club Atlético Osasuna, Luis Sabalza Iriarte, will talk about ‘Working beyond retirement age’. He will share experiences from his career in the Club.

In addition, three strategic actions will take place in the upcoming months in Navarra. Firstly, a cross-border record will be established of people aged 65 and over who are interested in getting information or taking part in gerontechnology and clinical research programmes.

Simultaneously, Clinical and Innovation Research Travelling Teams will be established where professionals specialising in various medical fields will transfer clinical and research practice to urban and rural areas, thus ensuring broader penetration and larger participation for the population. The teams will be made of doctors, nurses, physiotherapists and occupational therapists.

Also, a database will be created with data provided voluntarily by frail old people and old adults with memory disorders, which will be used to design research projects involving all the centres participating in the project.

Lastly, the members of the project will participate in the validation of a new concept, ‘intrinsic capacity’, as defined by the World Health Organisation (WHO), which might be used in the clinical assessment of old people.

Recently published studies

The actions framed within the project are in line with the conclusions drawn in a study published recently in JAMA Internal Medicine, the peer-reviewed medical journal of the American Medical Association.

Professor Mikel Izquierdo Redín, Director of the Department of Medical Sciences at UPNA and senior researcher from the Physical Exercise and Frailty Research Unit at Navarrabiomed, presented a study that shows that a tailored physical activity plan for in-patients aged 75 or older reduces functional decline. The clinical trial consisted in a three-year follow-up of 370 patients in the Geriatrics Service of CHN.

The study reveals that preadmission health and functional status can indicate the risk of functional decline associated with hospitalisation. This clinical sign might be negatively affected by bed rest during hospitalisation.

Simultaneously, the team is participating in the DIABFRAIL LATAM European project, funded by the European Commission in the context of the Horizon 2020 European research project. DIABFRAIL LATAM focuses on pre-frail and frail old people with diabetes in Latin America. At present, 40 per cent of people aged 65 and older are affected by diabetes.

The project’s goal is to implement a treatment model in Colombia, Chile, Mexico, Peru and Argentina, consisting of physical exercise, education and a nutrition plan, plus blood sugar level and blood pressure goals adjusted to old adults with diabetes, who are particularly vulnerable as a result of their frailty. More than 1000 pre-frail and frail old people with type 2 diabetes are taking part in the clinical trial.

www.aptitude-net.com / aptitude@navarra.es

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Spot Fragilidad - APTITUDE Navarra
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Nicolás
Martínez Velilla
Head of the Unit
Visor 360º
360º Virtual Tour
Functional training space
Installations
Colaboradores/as
Casadamon Munarriz, Irache
Servicio de Geriatría, HUN
Cedeño Veloz, Bernardo Abel
Servicio de Geriatría, HUN
Chen, Chenhui
Servicio de Geriatría, HUN
Gutiérrez Valencia, Marta
Servicio de Geriatría, HUN
Lozano Vicario, Lucía
Servicio de Geriatría, HUN
Marín Epelde, Itxaso
Servicio de Geriatría, HUN
Unidad de investigación / Grupo Vinculado
Contacto
Geriatrics and Active Ageing (INGEA)

Navarrabiomed - Centro de investigación biomédica
Complejo Hospitalario de Navarra, edificio de investigación.
Calle Irunlarrea, 3. 31008 Pamplona, Navarra, España.