Protein structure

Contrato financiado por la convocatoria de Ayudas para la contratación de personal investigador. Programa MRR Investigo 2022.

financiado por la Unión Europea – Next Generation EU

Project funded within the framework of the New Aquitaine - Euskadi - Navarra Euroregion, a common space for cooperation to promote projects that contribute to the economic, social and cultural development of the Euroregion on a cross-border, interregional and European scale.

This project focuses on the generation of short peptide libraries for the discovery and subsequent characterization of artificial epitopes that can bind to any type of detection antibody. The project will also work on developing the concept of a microfluidic method based on fluorescence polarization and classifying peptides with affinity for certain antibodies.

EPINPOC is a project led by the CIC biomaGUNE (Euskadi), with the participation of the CNRS (Nouvelle-Aquitaine). Navarrabiomed's participation is directed by Jacinto López Sagaseta, member of the Protein Crystallography and Structural Immunology Unit.

The recognition of autoantigens by immune cells, such as B or T cells, is an event that can trigger toxic activity against one self’s tissues, a mechanism frequently linked to autoimmune diseases. In type 1 diabetes, the destruction of insulin-producing pancreatic beta cells by autoreactive T lymphocytes leads to the deficiency of this hormone. In this project, the team of the Unit of Protein Crystallography and Structural Immunology of Navarrabiomed sets out to reveal the mechanisms that make these recognitions take place at the molecular level between well-defined cell membrane proteins. And it is precisely the intermolecular interactions between these proteins that the researchers will analyze with cutting-edge structural biology approaches.

This project is funded by EFSD / Lilly European Diabetes Research Programme.

The aim of this proposal is the development of peptide-based molecules with SARS-CoV-2 neutralizing properties for treatment of patients requiring of hospitalization and clinical survey due to severity of infection by SARS-COV-2

Los contratos Ramón y Cajal tienen como objetivo promover la incorporación de investigadores españoles y extranjeros con una trayectoria destacada en centros de I+D mediante la concesión de ayudas de una duración de cinco años para su contratación laboral y una financiación adicional para la ejecución de la actividad de investigación que se realice.

Navarrabiomed participa en este proyecto colaborativo con la Universidad Pública de Navarra como coordinadora técnica. La finalidad de estas ayudas es impulsar la capacitación, consolidación, colaboración y coordinación de los Centros tecnológicos y Organismos de investigación y difusión de conocimientos radicados en Navarra.
Resolución 245E/2018