Protein Crystallography and Structural Immunology

The Protein Crystallography and Structural Immunology Unit investigates the molecular and structural bases that regulate the presentation and recognition of both foreign antigens( those originating from pathogens or tumors) and self-antigens, the latter being associated with autoimmune diseases.

To achieve this, the research team combines protein engineering and structural determination techniques, such as X-ray crystallography, among others.

The studies being conducted are focused on revealing previously deciphered mechanisms and pathways involved in antigen presentation related to the immune response in scenarios of susceptibility to self and foreign antigens. The team's goal is to ensure that the results of their studies contribute to the development of medicines for the treatment and cure of diseases.

Research lines and areas of interest:

•    TCR-pMHC and antibody-antigen structure.
•    In silico design of high-affinity peptides.
•    Molecular Docking
•    TCR-pMHC and Fab-antigen structure.
•    Molecular mimicry.
•    Structural bases of antigen recognition.
•    Pathogen-host interaction.
•    Vaccine development.