JPND 2022 call - Neurodegenerative Disease Research

JPND (EU Joint Programme – Neurodegenerative Disease Research): Understanding the mechanisms of non-pharmacological interventions

This transnational call invites proposals for ambitious, innovative, multinational and multidisciplinary collaborative research projects aimed at improving the understanding of the mechanisms and biological substrates that underlie non-pharmacological interventions, in order to tailor a holistic personalised treatment approach

Proposals must focus on one or several of the following neurodegenerative diseases:

• Alzheimer’s disease and other dementias
• Parkinson’s disease and PD‐related disorders
• Prion diseases
• Motor neuron diseases
• Huntington’s disease
• Spinocerebellar ataxia (SCA)
• Spinal muscular atrophy (SMA)

Proposals submitted under this call may include, but are not limited to, the following types of
research:

• Determining biomolecular and/or physical underpinnings of effects of non-pharmacological interventions;
• Examining the mechanisms of effective non-pharmacological interventions on the molecular and cellular level by applying cutting-edge technologies;
• Identification of the mechanisms of non-pharmacological interventions within the brain, using brain imaging, electrophysiology and other equivalent state-of-the-art techniques;
• Identification of biological, psychological and social health markers and their associations to allow the identification of modifiable risk factors amenable to non-pharmacological interventions and better predict and monitor the effects of these interventions for future large-scale clinical studies;
• Elaborating modified concepts of non-pharmacological interventions with enhanced efficacy based on a deeper understanding of the mechanisms;
• Identification of potential drug-target sites for a combination of pharmacological and non-pharmacological interventions;
• Finding (individual) factors that predict response to interventions